Human Gene KIF15 (ENST00000326047.9_3) from GENCODE V45lift37 (2024)

FAQs

What is the function of kinesin 15? ›

Kinesin family member 15 promotes cancer stem cell phenotype and malignancy via reactive oxygen species imbalance in hepatocellular carcinoma. Identification of KIF15 as a potential therapeutic target and prognostic factor for glioma. KIF15 contributes to cell proliferation and migration in breast cancer.

Human gene transfer is experimental and is being studied to see whether it could treat certain health problems by compensating for defective genes, producing a potentially therapeutic substance, or triggering the immune system to fight disease.

However, the specific Notch2NL gene is found only in humans, and is absent from the DNA of chimpanzees, orangutans, and other great apes.

GENCODE is a scientific project in genome research and part of the ENCODE (ENCyclopedia Of DNA Elements) scale-up project. The GENCODE consortium was initially formed as part of the pilot phase of the ENCODE project to identify and map all protein-coding genes within the ENCODE regions (approx. 1% of Human genome).

Mutations in the KIF21B kinesin gene cause neurodevelopmental disorders through imbalanced canonical motor activity.

These parents are sometimes called "carriers" of the disease because they "carry" the genetic change that causes the disease or condition but do not have the disease themselves. A parent who is a carrier of a disease has a 50% (1 in 2) chance of passing the gene with the genetic change on to each of their children.

The gene regulatory proteins allow the individual genes of an organism to be turned on or off specifically. Different selections of gene regulatory proteins are present in different cell types and thereby direct the patterns of gene expression that give each cell type its unique characteristics.

KAT6A syndrome is an extremely rare genetic neurodevelopmental disorder. It can cause a wide range of symptoms with each child affected differently to the other. Common symptoms however include intellectual disability, developmental delays, speech delays and hypotonia.

High intelligence, cognition, and the capacity for reasoning that the human brain enables are so central to the human condition as to be inseparable from what makes us uniquely human.

Has our DNA been altered? ›

Humans continue to evolve with the emergence of new genes. Researchers have been looking into the evolution of human genetics. They say they have discovered that human genes have continued to change after the evolutionary split from primate ancestors.

​Genetic Code

Each gene's code uses the four nucleotide bases of DNA: adenine (A), cytosine (C), guanine (G) and thymine (T) — in various ways to spell out three-letter “codons” that specify which amino acid is needed at each position within a protein.

The Gene transfer format (GTF) is a file format used to hold information about gene structure. It is a tab-delimited text format based on the general feature format (GFF), but contains some additional conventions specific to gene information.

Kinesins are microtubule-based motor proteins that are well known for their key roles in cell biological processes ranging from cell division, to intracellular transport of mRNAs, proteins, vesicles, and organelles, and microtubule disassembly.

Kinesins are a large family of motor proteins that move cargoes along microtubules. However, some members of the Kinesin 1 subfamily, including KIF2A, do not function as motor proteins but possess microtubule-destabilization activity (Kornack and Giger, 2005).

Kinesin-14 proteins, including Drosophila Non-claret dysjunctional (Ncd), represent an evolutionarily conserved subfamily that function as meiotic/mitotic-specific motors, participating in spindle assembly, spindle pole organization, and chromosome dynamics.

Kinesin-5 motors perform essential functions in spindle dynamics by binding to and moving along MTs. Because of their bipolar structure, these motors can crosslink and slide apart anti-parallel spindle MTs (Figure 1 and Figure 2), thus providing the outwardly-directed force that separates the spindle poles.