Human Gene KIF2B (ENST00000268919.6_3) from GENCODE V45lift37 (2024)

Human Gene KIF2B (ENST00000268919.6_3) from GENCODE V45lift37

Description: hom*o sapiens kinesin family member 2B (KIF2B), mRNA. (from RefSeq NM_032559)
Gencode Transcript: ENST00000268919.6_3
Gencode Gene: ENSG00000141200.8_7
Transcript (Including UTRs)
Position:hg19 chr17:51,900,288-51,902,554Size:2,267Total Exon Count:1Strand:+
Coding Region
Position:hg19 chr17:51,900,395-51,902,416Size:2,022Coding Exon Count:1

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC:2024-04-24 11:59:55

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:51,900,288-51,902,554)			mRNA (may differ from genome)		Protein (673 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
GeneNetwork	HGNC	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: KIF2B_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF2B; FUNCTION: Plus end-directed microtubule-dependent motor required for spindle assembly and chromosome movement. Has microtubule depolymerization activity. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Association with kinetochore is transient. TISSUE SPECIFICITY: Highest level in lung. High level in ovary, moderate levels in heart, kidney, placenta, skeletal muscle and spleen (at protein level). Pancreas and spleen express a shorter isoform (at protein level). MISCELLANEOUS: Osteosarcoma cells (U2OS) lacking KIF2B show disorganised often monopolar mitotic spindles, severely reduced velocity of chromosome movement and blocked cytokinesis. Bipolar mitotic spindles can be restored by simultaneous depletion of KIF2B, KIFC1 and NUMA1. SIMILARITY: Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. SIMILARITY: Contains 1 kinesin-motor domain.

Primer design for this transcript


	Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Click here to load the transcript sequence and exon structure into Primer3Plus Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. Click here to open Exonprimer with this transcript To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: KIF2B Diseases sorted by gene-association score: charcot-marie-tooth disease, type 4c (9), hereditary neuropathies (5)

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 79.93 RPKM in Testis Total median expression: 80.00 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Highest median expression: 79.93 RPKM in Testis
Total median expression: 80.00 RPKM

View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-35.40	107	-0.331	Picture	PostScript	Text
3' UTR	-24.80	138	-0.180	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019821 - Kinesin_motor_CS
IPR001752 - Kinesin_motor_dom

Pfam Domains:
PF00225 - Kinesin motor domain
PF16796 - Microtubule binding

SCOP Domains:
52540 - P-loop containing nucleoside triphosphate hydrolases

ModBase Predicted Comparative 3D Structure on Q8N4N8


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003777 microtubule motor activity GO:0005524 ATP binding GO:0008017 microtubule binding GO:0016887 ATPase activity Biological Process: GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007018 microtubule-based movement GO:0007019 microtubule depolymerization GO:0007049 cell cycle GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0051301 cell division GO:0051310 metaphase plate congression GO:0051983 regulation of chromosome segregation Cellular Component: GO:0000775 chromosome, centromeric region GO:0000776 kinetochore GO:0000777 condensed chromosome kinetochore GO:0005694 chromosome GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005815 microtubule organizing center GO:0005819 spindle GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005871 kinesin complex GO:0005874 microtubule GO:0015630 microtubule cytoskeleton GO:0045171 intercellular bridge GO:0072686 mitotic spindle

Molecular Function:
GO:0000166 nucleotide binding
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0016887 ATPase activity

Biological Process:
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER
GO:0007018 microtubule-based movement
GO:0007019 microtubule depolymerization
GO:0007049 cell cycle
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0051301 cell division
GO:0051310 metaphase plate congression
GO:0051983 regulation of chromosome segregation

Cellular Component:
GO:0000775 chromosome, centromeric region
GO:0000776 kinetochore
GO:0000777 condensed chromosome kinetochore
GO:0005694 chromosome
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005871 kinesin complex
GO:0005874 microtubule
GO:0015630 microtubule cytoskeleton
GO:0045171 intercellular bridge
GO:0072686 mitotic spindle

Descriptions from all associated GenBank mRNAs


	HM005705 - homo sapiens clone HTL-T-82P testis tissue sperm-binding protein Li 82P mRNA, complete cds. AK057272 - homo sapiens cDNA FLJ32710 fis, clone TESTI2000699, moderately similar to KINESIN-LIKE PROTEIN KIF2. AF333335 - homo sapiens kinesin mRNA, complete cds. JD197716 - Sequence 178740 from Patent EP1572962. JD452891 - Sequence 433915 from Patent EP1572962. BC033802 - homo sapiens kinesin family member 2B, mRNA (cDNA clone MGC:44865 IMAGE:5170969), complete cds. JD147878 - Sequence 128902 from Patent EP1572962. AK302262 - homo sapiens cDNA FLJ53902 complete cds, highly similar to homo sapiens kinesin family member 2B (KIF2B), mRNA. AK308265 - homo sapiens cDNA, FLJ98213. JD041512 - Sequence 22536 from Patent EP1572962. JD247291 - Sequence 228315 from Patent EP1572962. JD119630 - Sequence 100654 from Patent EP1572962. CU689754 - Synthetic construct homo sapiens gateway clone IMAGE:100020003 5' read KIF2B mRNA. JF432265 - Synthetic construct homo sapiens clone IMAGE:100073437 kinesin family member 2B (KIF2B) gene, encodes complete protein. KJ899816 - Synthetic construct homo sapiens clone ccsbBroadEn_09210 KIF2B gene, encodes complete protein. JD067323 - Sequence 48347 from Patent EP1572962. JD362249 - Sequence 343273 from Patent EP1572962. JD156676 - Sequence 137700 from Patent EP1572962. JD092441 - Sequence 73465 from Patent EP1572962. JD559405 - Sequence 540429 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q8N4N8 (Reactome details) participates in the following event(s): R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-990489 Kinesin-13 is a dimer R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-983266 Kinesins bind microtubules R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-983189 Kinesins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-983231 Factors involved in megakaryocyte development and platelet production R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-109582 Hemostasis R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction R-HSA-2132295 MHC class II antigen presentation R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-1280218 Adaptive Immune System R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-168256 Immune System R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-199991 Membrane Trafficking R-HSA-5653656 Vesicle-mediated transport

Reactome (by CSHL, EBI, and GO)

Protein Q8N4N8 (Reactome details) participates in the following event(s):

R-HSA-141409 Mad1 binds kinetochore
R-HSA-375302 Kinetochore capture of astral microtubules
R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores
R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2
R-HSA-990489 Kinesin-13 is a dimer
R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex
R-HSA-141439 Release of activated MAD2 from kinetochores
R-HSA-2467811 Separation of sister chromatids
R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin
R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores
R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1
R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin
R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres
R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres
R-HSA-983266 Kinesins bind microtubules
R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules
R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-68877 Mitotic Prometaphase
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-983189 Kinesins
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-141424 Amplification of signal from the kinetochores
R-HSA-68886 M Phase
R-HSA-195258 RHO GTPase Effectors
R-HSA-983231 Factors involved in megakaryocyte development and platelet production
R-HSA-68882 Mitotic Anaphase
R-HSA-69618 Mitotic Spindle Checkpoint
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-194315 Signaling by Rho GTPases
R-HSA-109582 Hemostasis
R-HSA-2555396 Mitotic Metaphase and Anaphase
R-HSA-69620 Cell Cycle Checkpoints
R-HSA-1640170 Cell Cycle
R-HSA-162582 Signal Transduction
R-HSA-2132295 MHC class II antigen presentation
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-1280218 Adaptive Immune System
R-HSA-8856688 Golgi-to-ER retrograde transport
R-HSA-168256 Immune System
R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic
R-HSA-199991 Membrane Trafficking
R-HSA-5653656 Vesicle-mediated transport

Other Names for This Gene


	Alternate Gene Symbols: ENST00000268919.1, ENST00000268919.2, ENST00000268919.3, ENST00000268919.4, ENST00000268919.5, KIF2B_HUMAN, NM_032559, Q8N4N8, Q96MA2, Q9BXG6, uc317ipf.1 UCSC ID: ENST00000268919.6_3 RefSeq Accession: NM_032559 Protein: Q8N4N8 (aka KIF2B_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.

Human Gene KIF2B (ENST00000268919.6_3) from GENCODE V45lift37 (2024)

FAQs

Where is the human gene found? ›

The human genome is a complete set of nucleic acid sequences for humans, encoded as DNA within the 23 chromosome pairs in cell nuclei and in a small DNA molecule found within individual mitochondria. These are usually treated separately as the nuclear genome and the mitochondrial genome.

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Along with identifying all of the approximately 20,000–25,000 genes in the human genome (estimated at between 80,000 and 140,000 at the start of the project), the Human Genome Project also sought to address the ethical, legal, and social issues that were created by the onset of the project.

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Genetic Code

Each gene's code uses the four nucleotide bases of DNA: adenine (A), cytosine (C), guanine (G) and thymine (T) — in various ways to spell out three-letter “codons” that specify which amino acid is needed at each position within a protein.

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We now know that the human genome contains about 19,900 genes used to produce proteins. Typically, people have two copies of each gene, one inherited from each parent. Most genes are the same in all people, but a small number of genes (less than 1 percent of the total) are slightly different between people.

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DNA is the hereditary material in humans and almost all other organisms. Most DNA is located in the cell nucleus (where it is called nuclear DNA), but a small amount of DNA can also be found in the mitochondria (where it is called mitochondrial DNA). DNA contains the code for building and maintaining an organism.

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Genes are contained in chromosomes, which are in the cell nucleus. A chromosome contains hundreds to thousands of genes. Every normal human cell contains 23 pairs of chromosomes, for a total of 46 chromosomes.

Human Gene KIF2B (ENST00000268919.6_3) from GENCODE V45lift37 (2024)

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References