Human Gene KIF15 (ENST00000326047.9_3) from GENCODE V45lift37
Description: hom*o sapiens kinesin family member 15 (KIF15), mRNA. (from RefSeq NM_020242) Gencode Transcript: ENST00000326047.9_3 Gencode Gene: ENSG00000163808.17_11 Transcript (Including UTRs) Position:hg19 chr3:44,803,286-44,894,748Size:91,463Total Exon Count:35Strand:+ Coding Region Position:hg19 chr3:44,803,358-44,894,227Size:90,870Coding Exon Count:35
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Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
ID: KIF15_HUMAN DESCRIPTION: RecName: Full=Kinesin-like protein KIF15; AltName: Full=Kinesin-like protein 2; Short=hKLP2; AltName: Full=Kinesin-like protein 7; AltName: Full=Serologically defined breast cancer antigen NY-BR-62; FUNCTION: Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly (By similarity). SUBUNIT: Interacts with MKI67 and TPX2. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Detected during mitosis on the mitotic spindle. Colocalizes with TPX2 in mitosis. Localizes at the central spindle at anaphase (By similarity). Localizes at the sites of invagin*ting cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells (By similarity). Colocalizes with actin in interphase (By similarity). Colocalizes in dendrites and in growth cone of axons with microtubules (By similarity). TISSUE SPECIFICITY: Expressed in testis, colon, thymus and in breast cancer. SIMILARITY: Belongs to the kinesin-like protein family. KLP2 subfamily. SIMILARITY: Contains 1 kinesin-motor domain. SEQUENCE CAUTION: Sequence=AAG48261.1; Type=Frameshift; Positions=Several; |
Primer design for this transcript
Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA. Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence. To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3 |
MalaCards Disease Associations
MalaCards Gene Search: KIF15 Diseases sorted by gene-association score: thrombocytopenia robin sequence* (350), breast cancer (2) * = Manually curated disease association |
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Highest median expression: 9.78 RPKM in Testis Total median expression: 33.90 RPKM View in GTEx track of Genome BrowserView at GTEx portalView GTEx Body Map |
mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have. |
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR024658 - Kinesin-like_KLP2 IPR001752 - Kinesin_motor_dom Pfam Domains: SCOP Domains: ModBase Predicted Comparative 3D Structure on Q9NS87
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000166 nucleotide binding GO:0003677 DNA binding GO:0003774 motor activity GO:0003777 microtubule motor activity GO:0005515 protein binding GO:0005524 ATP binding GO:0008017 microtubule binding GO:0016887 ATPase activity Biological Process: Cellular Component: |
Descriptions from all associated GenBank mRNAs
LF384607 - JP 2014500723-A/192110: Polycomb-Associated Non-Coding RNAs. AB035898 - hom*o sapiens hklp2 mRNA for kinesin-like protein 2, complete cds. AK307674 - hom*o sapiens cDNA, FLJ97622. BC143752 - hom*o sapiens cDNA clone IMAGE:9052266. BC117174 - hom*o sapiens kinesin family member 15, mRNA (cDNA clone MGC:150783 IMAGE:40125725), complete cds. MA620184 - JP 2018138019-A/192110: Polycomb-Associated Non-Coding RNAs. JD536052 - Sequence 517076 from Patent EP1572962. JD453899 - Sequence 434923 from Patent EP1572962. LF378949 - JP 2014500723-A/186452: Polycomb-Associated Non-Coding RNAs. MA614526 - JP 2018138019-A/186452: Polycomb-Associated Non-Coding RNAs. AL832908 - hom*o sapiens mRNA; cDNA DKFZp762D1914 (from clone DKFZp762D1914). AK098533 - hom*o sapiens cDNA FLJ25667 fis, clone TST03527, highly similar to hom*o sapiens hklp2 mRNA for kinesin-like protein 2. LF378954 - JP 2014500723-A/186457: Polycomb-Associated Non-Coding RNAs. AF308294 - hom*o sapiens serologically defined breast cancer antigen NY-BR-62 mRNA, partial cds. AK027816 - hom*o sapiens cDNA FLJ14910 fis, clone PLACE1006368, weakly similar to HYALURONAN-MEDIATED MOTILITY RECEPTOR. LF378959 - JP 2014500723-A/186462: Polycomb-Associated Non-Coding RNAs. LF378962 - JP 2014500723-A/186465: Polycomb-Associated Non-Coding RNAs. JD183246 - Sequence 164270 from Patent EP1572962. JD401004 - Sequence 382028 from Patent EP1572962. JD438386 - Sequence 419410 from Patent EP1572962. MA614531 - JP 2018138019-A/186457: Polycomb-Associated Non-Coding RNAs. MA614536 - JP 2018138019-A/186462: Polycomb-Associated Non-Coding RNAs. MA614539 - JP 2018138019-A/186465: Polycomb-Associated Non-Coding RNAs. |
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_ranMSpathway - Role of Ran in mitotic spindle regulation Reactome (by CSHL, EBI, and GO) Protein Q9NS87 (Reactome details) participates in the following event(s): R-HSA-984821 Kinesin-12 is a dimer |
Alternate Gene Symbols: ENST00000326047.1, ENST00000326047.2, ENST00000326047.3, ENST00000326047.4, ENST00000326047.5, ENST00000326047.6, ENST00000326047.7, ENST00000326047.8, KIF15_HUMAN, KLP2, KNSL7, NM_020242, Q17RV9, Q69YL6, Q96JX7, Q9H280, Q9NS87, uc317rzf.1 UCSC ID: ENST00000326047.9_3 RefSeq Accession: NM_020242 Protein: Q9NS87 (aka KIF15_HUMAN) |